Link to pubmed/my publications
(please
SCROLL DOWN for "Publications" and "Awards" )

References

available from WORLD leaders in Cancer Research and Immunology:

1) Prof. Irving L. Weissman, Stanford University - Nobel candidate
2) Prof. Eugene C. Butcher, Stanford University - Nobel equivalent
3) Prof. Paul Kleihues, Zürich - Dir. emeritus I.A.R.C (=WHO cancer research center), former Dean Med. School, Zürich
4) Prof. Heinz Höfler, München - former Dir. Pathology, TUM









Irving L. Weissman
(Stanford University, Nobel candidate for cancer stem cells):
"Robert Eibl came to me ... with a very fascinating finding - he showed a role of integrin alpha4beta1 [=VLA-4] using the adhesion process of experimental metastatic melanoma cells.... I happily agreed ... and have been delighted to watch him develop the project ... to an important set of publishable findings. ... articulate and intelligent scientist.  ... I beleive that he is extremely good, and ready to enter ... a beginning research position...."

Eugene C. Butcher
(Nobel-equivalent/Crafoord prize winner 2004, Stanford University):      
"....  Robert initiated and  independently carried out studies of CD44 and also a4 integrin involvement in metastatic melanoma cell interactions with vascular endothelium under shear, revealing a critical role for a4b1 [=VLA-4] in particular. Irv Weissman, ... feels that Robert's observations represent a significant contribution to the field. Moreover, these studies were pursued with remarkable independence by Robert. ... he clearly has the potential to contribute to our understanding of the metastatic process. Like Irv, I feel his record of independence make him ready for ... independent research position...."

Paul Kleihues
(Director Emeritus IARC / WHO cancer research center):     
"... He was able to rapidly acquire new laboratory techniques and exhibeted an unusual depth of conceptual thinking. ... A total of 11 publications resulted from his work in our laboratory... I can fully recommend Dr. Robert Eibl for a position in basic medical research..."

Heinz Höfler
(Director Pathology / Technical University of Munich):    
" .... his newest and very fascinating set of findings use atomic-force microscopy to detect adhesion between two living cells on the level of single-molecules. This clearly is pioneering work and supports  his view of tumor metastasis... I can recommend Dr. Eibl as a highly motivated researcher able to develop independent and important contributions to any field of his choice. ..."  

(from a supporting letter to the American Heart Association)
Assoc. Prof. Vincent T. Moy, Ph.D. also confirmed my AFM related expertise:
"In particular, the expertise in the AFM technique that he [Robert Eibl, MD] has gained while a member of Dr. Hermann Gaub’s group will be an important asset in his proposed research. To assist Dr. Eibl in achieving his fullest potential [... blablabla snipped]. Dr. Eibl will also be able to consult with collaborators such as Dr. Ronen Alon (Group leader, Immunology, Weizman Institute, Rehovot, Israel; presently Harvard University, Boston), Prof. Dr. Horst Kessler (Head of Organic Chemistry, Technical University of Munich, Germany), Prof. Hermann E. Gaub (Head of Applied Physics, LMU – University of Munich, Germany)."


Publications
 


43 (submitted, April 2023)
Liquid Biopsy and Cancer
Eibl and Schneemann
Integrated Science for Sustainable Development Goal 3:
Universal Good Health and Well-being.
SPRINGER NATURE (invited book chapter)


42
Medulloblastoma Diagnosis
ENCYCLOPEDIA (04 March 2023)
URL: https://encyclopedia.pub/entry/41874


40
Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy.
Biology 2023, 12, 267. https://doi.org/10.3390/biology12020267


39 (preprint)
Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy. Preprints 2022, 2022120300 doi: 10.20944/preprints202212.0300.v1

38 (preprint)
Liquid biopsy and glioblastoma. Preprints 2022, 2022120363. https://doi.org/10.20944/preprints202212.0363.v1.

37
Liquid Biopsy for Monitoring Medulloblastoma
Eibl RH and Schneemann M
Extracellular Vesicles and Circulating Nucleic Acids
(September 2022) DOI: 10.20517/evcna.2022.36
(with COVER picture !!! and Cover story)


36
Eibl RH and Schneemann M
Extracellular Vesicles and Circulating Nucleic Acids (August 2022)


35 Liquid Biopsy of Brain Tumors
Robert Eibl  
ENCYCLOPEDIA (Dec. 2021)


34
Eibl RH and Schneemann M
Academic Editors: Nikolas von Bubnoff and Florian Scherer
Cancers 2021, 13(21), 5429;
https://doi.org/10.3390/cancers13215429
(HIGH IMPACT FACTOR, I.F. = 6.639)


33
Community Standards for Open Cell Migration Data
Gonzalez-Beltran AN, Masuzzo P, Ampe C, Bakker GJ, Besson S, Eibl RH et al.
Gigascience, 9, 5 (2020), Oxford academic (very good journal, high impact factor I.F. ~7 !)
https://academic.oup.com/gigascience/article/9/5/giaa041/5836133?searchresult=1


32-28 (Rxiv, or in preparation, snipped)

27
Eibl RH
Comment on "A method to measure cellular adhesion utilizing a polymer micro-cantilever" [Appl. Phys. Lett. 102, 123702 (2013)]

26                           (33 pages)
(1/2013 - available online - click on link):
Single-Molecule Studies of Integrins by AFM-Based Force Spectroscopy on Living Cells
Scanning Probe Microscopy in Nanoscience and Nanotechnology 3
137-169, ISBN 978-3-642-25414-7_6 (2013)
2.3k paid Downloads (!!!)


25                            (19 pages)
Eibl, Robert H.
Cell adhesion receptors studied by AFM-based single-molecule force spectroscopy.
In: Scanning Probe Microscopy in Nanoscience and Nanotechnology 2, Bhushan B. (Editor), Springer, ISBN: 978-3-642-10496-1, p p. 197-215 (2011)

2.9k paid Dowonloads (!!!)


24
Eibl RH and Moy VT
Atomic force microscopy measurements of protein-ligand interactions on living cells
In: Protein-Ligand Interactions 
(Editor: G.Ulrich Nienhaus), Humana Press, Totowa, NJ, U.S.A., pp. 438-450, ISBN 978-1617375255 (2010)

3k paid Downloads (!!!)


23                            (31 pages)
Eibl, Robert H.
Direct Force Measurements of Receptor-Ligand Interactions on living cells.
In: Applied Scanning Probe Methods XII - Characterization. Bhushan B, Fuchs H (Editors), Springer, pp. 1-31, (2009)

22
Eibl RH
First measurement of physiologic VLA-4 activation by SDF-1 at the single-molecule level on a living cell.
In: Advances in Single Molecule Research for Biology and Nanoscience. Hinterdorfer P, Schuetz G, Pohl P (Editors),
Trauner, Linz, p40-43, ISBN 3854991630 (2007)

21
Eibl RH and Moy VT
Atomic force microscopy measurements of protein-ligand interactions on living cells
In: Protein-Ligand Interactions
(Editor: G.Ulrich Nienhaus), Humana Press, Totowa, NJ, U.S.A., pp. 437-448,
ISBN 1588293726 (2005)

3k paid Downloads (!!!)


20
Pax M, Rieger J, Eibl RH, Thielemann C, Johannsmann D
Measurements of fast fluctuations of viscoelastic properties with the quartz crystal microbalance
The Analyst, (130): 1474-1477 (2005)

19
Eibl RH
Atomic force microscopy measurement of SDF-1 mediated affinity modulation of single VLA-4 - VCAM-1 bonds
In: Immunology 2004: Cytokine Network, Regulatory Cells, Signaling and Apoptosis. Monduzzi Ed. (Editor: E. Skamene), MEDIMOND S.r.l., Bologna, Italy, (1):115-120 ISBN  978-88-7587-070-6 (2004)

18
Eibl RH, Benoit M
Molecular resolution of cell adhesion forces
IEE - Nanobiotechnology 151(3):128-132 (2004), ISSN: 1478-1581

17
Eibl RH and Moy VT
AFM-based adhesion measurements of single receptor-ligand bonds on living cells
In: Recent Research Developments in Biophysics, Transworld Research Network, Trivandrum, India, (3): 235-246, (2004)
ISBN 81-7895-130-4

16
Preuss I, Haas S, Eichhorn U, Eberhagen I, Kaufmann M, Beck T, Eibl RH, Dall P, Bauknecht T, Hengstler J, Wittig BM, Dippold W, Kaina B
Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue.
Cancer Detection and Prevention 1996;20(2):130-136

15
Eibl RH, Pietsch T, Moll J, Skroch-Angel P, Heider KH, von Ammon K, Wiestler OD, Ponta H, Kleihues P, Herrlich P
Expression of variant CD44 epitopes in human astrocytic brain tumors
Journal of Neuro-Oncology 1995 Dec;26(3):165-170

14
Preuss I, Eberhagen I, Haas S, Eibl RH, Kaufmann M, von Minckwitz G, Kaina B
O6-methylguanine-DNA methyltransferase activity in breast and brain tumors
International Journal of Cancer 1995 May 4;61(3):321-326

13
Eibl RH, Kleihues P, Jat PS, Wiestler OD
A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen
American Journal of Pathology 1994 Mar;144(3):556-564

12
Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring, M, Petersen I, Holl T, Wiestler OD, Kleihues P
Mutations  of the p53 tumor suppressor gene in neoplasms ofthe human nervous system
Molecular Carcinogenesis 1993;8(2):74-80
(Citations in Science Citation Index: >>150)

11
Louis DN, von Deimling A, Chung RY, Rubio MP, Whaley JM, Eibl RH, Ohgaki H, Wiestler OD, Thor AD, Seizinger BR
Comparative study of p53 gene and protein alterations in human astrocytic tumors
Journal of Neuropathology & Experimental Neurology 1993 Jan;52(1):31-38
(Citations in Science Citation Index: >>150)

10
Radner H, el-Shabrawi Y, Eibl RH, Brustle O, Kenner L, Kleihues P, Wiestler OD
Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose
Acta Neuropathologica (Berl) 1993;86(5):456-465

9
Wiestler OD, Brustle O, Eibl RH, Radner H, Von Deimling A,
Plate K, Aguzzi A, Kleihues P
A new approach to the molecular basis of neoplastic transformation in the brain
Neuropathology and Applied Neurobiology 1992 Oct;18(5):443- 453

8
Wiestler OD, Aguzzi A, Schneemann M, Eibl R, von Deimling A, Kleihues P
Oncogene complementation in fetal brain transplants
Cancer Research 1992 Jul 1;52(13):3760-3767

7
von Deimling A, Eibl RH, Ohgaki H, Louis DN, von Ammon K, Petersen I, Kleihues P, Chung RY, Wiestler OD, Seizinger BR
p53  mutations are associated with 17p allelic loss in grade II and grade III astrocytoma
Cancer Research 1992 May 15;52(10):2987-2990
(Citations in Science Citation Index: >>200)

6
Wiestler OD, Brustle O, Eibl RH, Radner H, Aguzzi A, Kleihues P
Retrovirus-mediated oncogene transfer into neural transplants
Brain Pathology 1992 Jan;2(1):47-59

5
Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P
p53 mutations in nonastrocytic human brain tumors
Cancer Research 1991 Nov 15;51(22):6202-6205
(Citations in Science Citation Index: >>150)

4
Wiestler OD, Brustle O, Eibl RH, Radner H, Aguzzi A, Kleihues P
Oncogene transfer into the brain
In: Recent Results in Cancer Research 1994;135:55-66

3
Kleihues P, Ohgaki H, Eibl RH, Reichel MB, Mariani L, Gehring, M, Petersen I, Höll T, von Deimling A, Wiestler OD, Schwab M
Type and frequency of p53 mutations in tumors of the nervous system and its coverings
In: Recent Results in Cancer Research 1994;135:25-31

3
Wiestler OD,  Aguzzi A, Brüstle O, Eibl R, Radner H, Kleihues P
Oncogene complementation in transgenic neural transplants
Neuropathology, 4:304-309 (1991)


2 Eibl RH, Wiestler OD. Induction of primitive neuroectodermal tumors following retrovirus-mediated transfer of SV40 large T antigen into neural transplants. Zülch symposium on growth control and neoplastic transformation in the brain. Clin Neuropathol 1991;10:248-9.


1b+c
Eibl R
Klonierung eines genomischen DNA-Fragments mit für Lamin C codierenden Sequenzen
Grin-Verlag, München, ISBN 3638951154 (1990/2008), (also avail. as e-book, 2008)

1
Eibl R
Klonierung eines genomischen DNA-Fragments mit für Lamin C codierenden Sequenzen
Grin-Verlag, München, e-Book: http://www.grin.com/e-book/93884 (1990/2008)



Awards, or similar

* "Marquis' Who's Who" exists since 19th century, i.e. this is the serious original - and, of course, I never paid anything for inclusion, I didn't nominate myself, nor did I buy anything from them.


2011 Marquis' Who's Who in SCIENCE and Engeneering
2010 Marquis' Who's Who in the WORLD
2009 Immunology Meeting/Heidelberg
2009 Marquis' Who's Who in MEDICINE and Healthcare
2006 Marquis' Who's Who in Medicine and Healthcare
2005 CNRS biphysics meeting Montpellier, France
2005 Poster Award, 1st Spring School on Immunology, Ettal, Bavaria
2004 GSO (German Scholar Organization) stipend/Travel support and Marriott Hotel Boston, presentation at Harvard Faculty Club
2004 Poster Presentation Award (500 EUR), DKFZ Heidelberg
2003 NIH-funded position, Co-Investigator, University of Miami
2002 Max Planck Society, travel/meeting participation awards (about 3.000 EUR) for American Association of Immunologists/ meetings at Stanford University/USA, Madrid/Spain, Lugano/Switzerland, Groningen/The Netherlands, Wiesbaden/Germany
2002 Travel Award (from Prof. Hermann E. Gaub, about 2000 EUR), Center for NanoScience and Ludwig Maximilians University of Munich
2002 Governmental DFG stipend for Keystone symposium/Steamboat Springs, CO, U.S.A. and to meet with Prof. Tim Springer (Harvard University)
2001 Travel awards (about 8.000 EUR) from Technical University of Munich/Prof. H. Höfler to: Stockholm/Sweden, Berlin/Germany, Stanford University/USA
2000 Winner of MBPW (1000 DM/500 EUR), Germany's largest regional business plan competition (Munich) - three additional nominations later, winning two business meetings at Castle Elmau/Bavaria (worth about 2.000 EUR)
1999 Deans fellowship, Stanford University (5.000 USD)
1999 Travel award to present at MRS - Metastasis Research Society meeting in San Diego (USD 1.000 support from Irving L. Weissman)
1999 Tuition sponsoring / Stanford University (about 7.000 USD; half from Weissman-lab)
1997 DFG stipend for Stanford University, U.S.A. (researcher salary) for 2 years
1996 DFG stipend for Harvard University (funding for 2 years)
1995 EU-funded Human Capital and Mobility Programm (stipend for The Institute of Molecular Biology and Biotechnology (IMBB) Heraklion, Crete, Greece, funding for 3 years; with Prof. Nicolas P. Anagnou)
1992 stipend from Nobel Laureate Prof. Georges Köhler / Max Planck Institute for Immunobiology - practical course / 2 weeks on gene targeting (only 8 international participants accepted)
1992 Travel award for meeting and presentation at Graz, University of Bonn, Institute of Neuropathology
1992 Research Center Karlsruhe - travel support for few meetings
1991 Basel Institute of Immunology - invited young investigator (20 international stipends)
1990 University of Zürich/Pathology (Proff. Kleihues/Heitz/Wiestler, and Nobel Laureate Rolf Zinkernagel) - Awarded to participate at Oncogene Meeting in Frederick,/USA, scientific visits in San Diego (SALK, UCSD) and Boston (Harvard University/MGH), total about 4.000 SFR.
1985 Invited by "Konrad-Adenauer Stiftung", an organization to support young talents, to a weekend in the Konrad Adenauer Haus, Bonn (Recommended by Proff. H. Schimassek and Prof. J. Bille, Heads of Biochemsitry and Physics, Univ. of Heidelberg) - I was confirmed to be one of the very best in the IQ-test (of the 1300 invited), but politically too clearly against the risks of nuclear energy - therefore not acceptable for a conservative ideology.
1984 Invited by the "Studienstiftung des Deutschen Volkes", an organization to support young talents, to a weekend in the Black Forest (Recommended by the Head of Physics, Professor Josef Bille, Heidelberg) - originally, I was told by a biophysicist from Freiburg to be accepted. Unfortunately, I was probably too expensive and then 6 professors' sons were accepted instead of me.
1986 University of Heidelberg: Summer exchange student at University of Montpellier, France
1985 University of Montpellier, Medical Faculty and Maison de Heidelberg, France: Medical Training and financial support (Prof. Pierre Carabalona, Head of Surgery, and Mr. Brenner, Director Maison de Heidelberg in Montpellier)
1983 Visiting student, Avignon, Montpellier, Perpignan, southern France (stipend)
1982 Teaching at school (Botanics and Chemistry)
1982 Exchange student, Sommieres, southern France (school award, stipend)
1981 Botanic Excursion, Gerardmer, France (school award)


Selected ABSTRACTS
(of >>50 Talks and Posters, not updated )


Eibl, Robert H.
Euro AFM Meeting (Munich 2009)
Fir
st single-molecule force measurement of physiologic activation of any integrin by any chemokine on any living cell

Eibl, RH
Vascular Biology 2007 (Heidelberg)
First force spectroscopy measurements of physiologic VLA-4 integrin activation by the chemokine SDF-1 at the single-molecule level on a living cell; Oktober 2007

Eibl, RH
DGFI-annual meeting (Deutsche Gesellschaft für Immunologie), plus  Satellite-Symposium (Cell Adhesion/Talk), Heidelberg , September 2007
First force spectroscopy measurements of physiologic VLA-4 integrin activation by the chemokine SDF-1 at the single-molecule level on a living cell


Eibl, RH
Cancer Immunotherapy Meeting, Würzburg, April 2007
First force spectroscopy measurements of physiologic VLA-4 integrin activation by the chemokine SDF-1 at the single-molecule level on a living cell

Eibl, RH
First force spectroscopy measurements of physiologic VLA-4 integrin activation by the chemokine SDF-1 at the single-molecule level on a living cell
International Meeting of Immunologists, Paris, France
Selected for Talk (September 2006)

Eibl, RH
International Biophysics Meeting at INSERM in Montpellier, France
June 2006
First force spectroscopy measurements of physiologic VLA-4 integrin activation by the chemokine SDF-1 at the single-molecule level on a living cell

Eibl, RH
30min Lecture in: Nanobiotechnology and Systems Biology, Munich Gene Center, 2005

Eibl, RH
Tumor Stem cell meeting at German Cancer Research Center, DKFZ,  Heidelberg

Eibl, RH
Alumni Meeting of the German Cancer Research  Center, DKFZ, Heidelberg

Eibl, RH
International Biophysics meeting at the University of Linz, Austria
2/2005 (registration stipend from Prof. Peter Hinterdorfer)

Eibl, RH
CNIO-Meeting, Spanish Cancer Research Center, Madrid (2004)

Eibl RH Benoit M, Weissman IL, Gaub HE, Moy VT
Single-Molecule Adhesion Forces between Living Cells: Chemokine Triggered Integrin Modulation Measured by AFM (Atomic-Force Microscopy)
Clinical and Investigative Medicine Suppl. 27(4), August 2004
(pioneering work),  07/2004 Presentation at: 12th International Congress of Immunology, ICI/FOCIS2004, Montreal, CANADA

Eibl RH , Weissman IL , Gaub HE , Benoit M
Adhesion measurements of integrin alpha(4)beta(1) – VCAM-1 interactions with AFM: analysis and modulation(!) of single-receptor bounds between living cells (2003, Meeting abstract: From Cells to Molecules – Research Center Juelich; Organizer: Rudi Merkel)

Benoit M, Eibl RH, Wieland U, Thie M, Gerisch G, Gaub HE
Cell adhesion force spectroscopy (2003, Meeting abstract: From Cells to Molecules – Research Center Juelich; Organizer: Rudi Merkel)

Thielemann C, Pax M, Rieger J, Eibl RH, Johannsmann D
Quartz Crystal Microbalance cell-based biosensor for druc screening
DECHEMA 2002, Wiesbaden

Eibl RH
Rapid arrest of metastasizing melanoma cells under flow conditions
VIRCHOWS ARCHIV, 2001, Vol. 439 (3), pp. 241-242

Eibl RH , Höfler H
The multistep homing model of tumor metastasis: from cell adhesion molecules to chemokine receptors
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2001, Vol. 54, Supplement 1, p. 50

Eibl RH, Kremer M, Herzog C, Kitsanta E, Fend F, Schlegel J, Hofler H
Role of metastasis-associated chemokine receptors in breast and brain tumors
ACTA NEUROPATHOLOGICA 102 (5): 523 NOV 2001

Eibl RH and Höfler H
The multistep homing model of tumor metastasis: From inflammatory cell adhesion molecules to chemokine receptors
Inflammation Research, 2001, Vol. 50, Supplement 3, p. 201

Eibl RH
From leukocyte trafficking to tumor cell metastasis: A new approach for the development of antimetastatic drugs
Biochemical Society Transactions, 2000, 28(5), A350

Eibl RH, Moll J, Pietsch T, Herrlich P. Specific transcrips of CD44 are frequently expressed in astrocytomas and glioblastomas. Congress of Molecular Medicine, Berlin, May 3-5, 1997

Preuss I, Eberhagen I, Haas S, Eibl RH, Kaufmann M, Beck T, Dippold W, Kaina B
Expression of O-6-methylguanine-DNA methyltransferase in human tumors
Mutation Research 1996;360(3):215

Preuss I, Eberhagen I, Haas S, Eibl RH, Kaufmann M, Beck T, Dippold W, Kaina B
Expression of 0(6)-methylguanine-DNA methyltransferase in human tumors
Cancer Detection and Prevention 1995; 19(1).
presented at the International Symposium on the Impact of Biotechnology on Predictive Oncology and Therapy; Boston, Massachusetts; December 11 - 13, 1994; in the section on Response, Resistance, Metastasis.

Eibl RH, Arch R, Toelg C, Zawadzki V, Heider KH, Rudy W, Wirth K,
 Matzku S, Pals S, Moll J, Sleeman JP, Hofman M, Zoeller M, Ponta
H, Herrlich P
Metastatic tumor cells expressing CD44 splice variants with the epitope v6
mimic an essential step of lymphocyte migration behavior.
EMBO Workshop on Cell-Cell Interactions in Leukocyte Homing and Differentiation,
Basel, CH, September 1-4, 1992

Eibl RH and Wiestler OD
Induction of primitive neuroectodermal tumors following retrovirus-mediated transfer of SV40 large T antigen into neural transplansts
Clinical Neuropathology 1991 10(5):244-245


Selected ORAL PRESENTATIONS
(not updated)

Eibl RH
Immunology meeting (Montreal, Canada, 2004)

Eibl RH
Invited to Harvard Faculty Club, presentation of AFM measurements on living cells

Eibl RH
Single-molecule adhesion forces of living metastatic tumor cells
1st International Meeting of DKFZ Alumni: Recent Research Results in Cancer Research. German Cancer Research Center, Heidelberg, GERMANY. 06/2004
WINNER OF POSTER PRESENTATION, (AWARD: EURO 500)

Eibl RH
Single-molecule adhesion forces between living cells: Chemokine triggered integrin modulation measured by AFM (atomic force microscopy) SFB/DFG seminar speaker (german research council), Institute of Anatomy (Prof. D. Drenckhahn), University of Würzburg Germany (06/2004)