to my private Homepage "under construction"

CONTACT:  robert.eibl(at)alumni.dkfz.de

- Heidelberg/Mannheim, Zürich (Switzerland), Karlsruhe, Stanford/Palo Alto (U.S.A.), München, Mainz, Miami (U.S.A.) - 




January 2019:

SUBMITTED phase 2 (of 3): Science4Life (Business plan competition)

New scientific manuscript (mainly supported by HORIZON 2020, the biggest, i.e. 80 billion EUR project of the EU) is ready for submission to first class journal (24 intl. authors, 39 pages) - I am just a co-author, i.e. not first or last author, but I am very honored having been invited to contribute.

I just missed by just one single vote (!) the inclusion in the management board (and the possibility to become director) of the DKFZ Alumni Association, which was founded by Nobel prize winner Harald zur Hausen. I hope the Alumni e.V. will not be taken down.


October - December, 2018

pitch presentation, Uni Heidelberg, Dec. 18th, 2018:






TEAM LEADER - with my pioneering, own "biotech-nanotech" project at the biotech entrepreneurschip course at the University of Heidelberg.

BACKGROUND. my book chapter (link - click here)

We are in excellent progress of preparing a university presentation for december for a biotech startup.

I/we would be happy about

- an investor with 1-4 Million EUR (seed money)

- access to some AFM (Atomic Force Microscope, custom-made OK, with only z-axis for force measurements; x-, y-axis not needed)

- cell culture lab (or fpart of a cell incubator to keep 3 mouse cell lines for for reference testing (lowest biosafety-level OK)

- after starting period to setup the system: access to cell culture lab to test also human blood samples, preferentially a University or clinical lab and very fresh blood samples from volounteers and patients


BTW, I once was placed 1st (!) in the final photo-video-composition of originally 39.000 participants in a Stanford online course on creativity... (offered by Prof. Tina Seelig) - I was the team lead of 14 from 11 countries all around the world - of course we all faced the challenge of having different ideas, views and, of course, the many different time zones - but nobody left my team :-)


Congratulations to the NOBEL PRIZE WINNER:

(invited Dr. Eibl congratulates Prof. Harald zur Hausen for his Nobel prize)



October 2018

NOBEL PRIZE in medicine goes to James P. Allison

  I was invited last year by the big MD Anderson cancer research center (USA) to join a conference in London: "Accelerating Cancer Immunotherapy" - I was very impressed by the talk of the future Nobel prize winner 2018 - who is from the MD Anderson center.


1-10 million EUR seed money or venture capital needed in Heidelberg, GERMANY (or in Palo Alto, USA or Munich). INVESTORS for biotech-/nanotech (AFM, medical or cancer research) for founding of a startup company are more than welcome ! 


I currently like to continue MY OWN, pioniered FIELD between Medicine, Physics, Cancer Research and Immunology, which I had pioniered in Munich and Miami earlier - but my projects were partly overtaken: Pharmacological (!!!) force changes with Atomic Force Microscopy (AFM) on a living cell at the level of single pairs of receptord and their induction, desensitization ...




September 16-19, 2018: STEM CELLS AND CANCER

someone said: "one of the premier meetings in this field"

I presented and published my abstract at the "10th International Behr-Symposium" at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ Heidelberg):


photos from abstract book - full text below: (also click here)


“Single-molecule” force measurements between living cells: AFM elucidates integrin activation by chemokines with implications in cancer stem cell trafficking


Robert H. Eibl (1,2,3,4,5)

(1) Stanford University, Irving L. Weissman - lab, Stanford, CA, USA

(2) Veterans Hospital, Eugene C. Butcher - lab, Palo Alto, CA, USA

(3) Technical University of Munich, Pathology, Munich, Germany

(4) University of Munich, Biophysics (guest), Munich, Germany

(5) University of Miami, Physiology and Biophysics, Miami, FL, USA


Chemokine-mediated integrin activation with rapid arrest on endothelium can easily be observed on lymphocytes using a flow chamber, mimicking the metastatic process of some solid tumors. Pioneering work with atomic force microscopy (AFM) resolved this adhesion at the so-called “single-molecule” (better: single-receptor) level between two living cells. The author became the very first to 1) further elucidate his independent metastasis model of rolling B16 melanoma cells (work at Stanford Univ.) to molecular resolution, i.e. measuring the molecular forces of individual VLA-4/VCAM-1 adhesion receptors between two living cells (work universities in Munich and Miami); 2) to detect similar, “specific” adhesion events between living lymphoma and either endothelial cells, or immobilized VCAM-1 fusion protein, respectively; and 3) to detect with his system the immediate activation of VLA-4 integrin receptors by a chemokine (CXCL12/SDF-1) at the single-molecule level and at the same time on an intact living cell. This very unique tool of measuring the activation state of metastasis-supporting cell adhesion receptors, as well as metastasis inhibiting repellent molecules will be evaluated for its use in the clinical management of metastatic solid tumors and leukemias.



1.     Eibl RH, Single-molecule studies of integrins by AFM-based force spectroscopy on living cells. In: Scanning Probe Microscopy in Nanoscience and Nanotechnology 3, Bhushan B. (Editor), Springer (2013)

2.     Eibl RH, Cell adhesion receptors studied by AFM-based single-molecule force spectroscopy. In: Scanning Probe Microscopy in Nanoscience and Nanotechnology 2, Bhushan B. (Editor), Springer, (2011)

3.     Eibl RH, Direct force measurements of receptor-ligand interactions on living cells. In: Applied Scanning Probe Methods XII - Characterization. Bhushan B, Fuchs H (Editors), Springer, pp. 1-31, (2009)

4.     Eibl RH and Moy VT, Atomic force microscopy measurements of protein-ligand interactions on living cells. In: Protein-Ligand Interactions, (Editor: G.Ulrich Nienhaus), Humana Press, Totowa, NJ, U.S.A., pp. 437-448, ISBN 1588293726 (2005)

5.     Eibl RH and Benoit M, Molecular resolution of cell adhesion forces. IEE - Nanobiotechnology 151(3):128-132 (2004)


 EXTINCT now in the USA : Miami Blue




Some of the WORLD's biggest Professors confirm (incl. a NOBEL PRIZE candidate, a official NOBEL PRIZE equivalent WINNER, and a director emeritus of the cancer research center of the World Health Organization, WHO).

BTW, I was awarded a stipend for Harvard University, with which I published my highly recognized papers on brain tumors. I started an identical stipend (salary) for two years as scientist later for Stanford University; at Stanford I also got a "Dean's fellowship"; I was also a volountary conflict counselor and mentor for colleagues (as part of the SUPD organization) in all cases relating to work environment, potential harassment, supervisors, pubulication conflicts, or anything related to potential conflicts - I think I helped with some support with a colleague to avoid a conflict and the person became later professor in Germany.


1)     " I beleive that he [Robert Eibl] is extremely good "

Irving "Irv" Weissman, Stanford University - a Nobel Prize candidate 2018 (for his cancer stem cell theory)

My anecdote with "Irv":

Irv really is the smartest professor I ever met: at a Stanford meeting in Asilomar, I showed him my scientific poster and he understood within seconds --- as the only person ever --- my paradoxical findings, although they appeared to be quite the opposite of his findings published in "Cell";  a few weeks later - I needed another, official sponsor at Stanford -  and after 10 min of the real interview, he gave me his OK that he would serve as my official sponsor at Stanford, although a few miles away from my workplace where I could continue to work as a guest scientist in Eugene Butcher's lab where I already had established my experimental nobel prize setup; then, Irv gave me about a one hour lecture on 50 years of research in my field - and how my findings may contribute to something in cell migration still totally unsolved, but which was his probably first Nature paper.


2)      " Like Irv, I feel his [Robert's] record of independence ... "

Eugene "Gene" Butcher, Stanford University - Crafoord prize / official Nobel equivalent winner 2004, (prize shared with Tim Springer/Harvard University; for his multi-step model of lymphocyte rolling and arrest, which I compared in Eugene's lab with organ-specific tumor metastasis - ironically, Eugene appeared to be interested originally in metastasis before he became such a successfull immunologist) - and one of Irv Weissman's most famous former students.


3)       " I can fully recommend Dr. Robert Eibl "

Paul Kleihues, Director Emeritus, I.A.R.C. (International Agency for Research on Cancer, World Health Organization/WHO, Lyon/France) - and former Medical Dean, Zürich/Switzerland, (WHO classification of Brain Tumors)



(to see more of these references, please scroll down to: "4 Academic References")




September 8, 2018

There were several rather large bats flying around at midnight just at one of many identical lanterns of  the street, but not at all the others, don't know why just this one, don't see many insects flying around ; since weeks I observe many, rather small bats around my balcony and windows.


August, 2018

After only almost 40 years, I found another, extremely rare, almost extinct, but huge moth in the Palatinate, where I live, called "Blaues Ordensband".


May 13, 2018: video of large black snake in German forest (click here)





May 14, 2018: my 1st sighting ever in Germany of, perhaps, the rarest, or at least a very rare butterfly (<- link to VIDEO, 8x slow motion), Iphiclides podalirius (Segelfalter) - I know those only from Spain/France.



My biggest success in science, I like to call it: "honor" - or should I call it an ongoing odyssey:

I developed my confidential project over years with no funding - then it was overtaken by collaborators:

A famous German professor of chemistry once directed one of his former PhD students to overtake my obviously Nobel-like projects in a biophysics lab. Before that, he happily shared two of his chemical compounds with me, which totally failed in his research setup (i.e. no good inhibitor, not patented). I also gave a lecture for his students, and he wrote -as he stated- a maximal supporting letter for my large grant application in the USA. I didn't become professor in the USA and to my surprise my projects and collaboration with Israel were overtaken in Munich - after I had shared confidential results from my former work at Stanford University and after I had invested three unpaid years in developing my setup and even initiating over years the collaboration with a former postdoc from another Nobel equivalent winners lab at Harvard.


Winning ceremony in Germany's largest regional (Munich) business plan competition (many years ago; I am on the right):

I won the first prize with about 500 EUR and a long, founders' weekend at Castle Elmau, Bavaria (were many years later the G7 summit took place); Later, I won again -as Nominee- the founders' weekend at Castle Elmau).

I am not sure if there really were 2.000 people celebrating the only ten winning teams of around 250 teams in the Hypovereinsbank building in Munich - I wasn't really told before that I would win !!! They only called earlier the day, if I would come to the announcement, so I was so happy that a busy friend was able to join me, she meanwhile got the Order of merit of Germany (Bundesverdienstkreuz).

Later, I got an offer for a start-up incubator with two free office rooms, incl. phone/fax lines for a few months; in addition I may have gotten 500.000 EUR seed capital and/or three half-day technicians for a year - but with commercial AFMs in a range of above 200.000 EUR I decided that I had no sufficient funds to start this endeavour and be successfull to get real funding fast - I think today, I was right, even another Munich startup from that round failed later although they published in Science (perhaps, they were also very science oriented and with no product or exit strategy).

More recently, I succeeded to be among the TOP20 in another German business plan competition: I presented within the "Technology SLAM" of "Science4Life" in the huge Lobby of the KfW (Kreditanstalt für Wiederaufbau) bank (I guess second biggest in the wolrd) in Frankfurt/M. in front of about 600 interested people, potential investors, patent lawers and colleagues - but my presentation was probably too funny (business suit, Stanford tie and a snowboard helmet with air filled gloves on my head - the hands were simulating activateable "adhesion receptors" of a migrating leukocyte or metastatic cell in the blood stream).


"A Nobel prize won't be that easy": to the best of my knowledge, I am the first who designed and performed the experiments with an atomic force microscope (AFM) to measure "specifically" the modulation of any cell adhesion receptors by any chemokine within the context of a living cell - and at the same time - at the (so-called) single-molecule level.

I would be more than happy to continue these, i.e. my, Nobel prize - experiments, anytime, anywhere.


Although not the Nobel prize, yet:

I got the FIRST PRIZE for my 20 min presentation: integrin alpha4beta1/VCAM-1/SDF-1 on living cells and at the single-molecule level (awarding committee: Prof. Garry Fathman, Stanford Univ. and Prof. Peter Bannasch, Heidelberg).



OLD pic: windsurfing remains my only favourite sport - well, I replaced it only partly with snowboarding.

Here a pic with my "sinker" windsurfing board - I made it through 9 Beaufort another day (just below hurricane!), was nice to meet the two world champions there, Robby Naish and his successor; just west of Gibraltar (the wind capital: Tarifa, Spain)

At that time, my parents run a watersport school an hour away near Marbella, Spain; so I also learned scuba diving (up to "rescue diver" certificate) and sailing (incl. catamaran; all major German certificates), but I still like windsurfing the most -  (since there never is enough wind in Germany and sunshine at the same time, my premium board is for sale now: 80 L Alpha, 30 y.o., technically like new, asking 200 EUR).



4 Academic References

(only from the "big shots"/Nobel equivalent and similar leaders)

Here are four selected citations from Letters Of Recommendation: this should easily document how long I developped my independent work on VLA-4 (as well as VCAM-1 and SDF-1) - basically since my time at Stanford University. I later also visited biophysics labs in Munich and Miami, where I shared my privileged results to those labs and continued my project on my own ideas - to what I think, should be the beginning of a Nobel prize. Unfortunately, others were allowed to continue my projects and I didn't get the expected funding in Miami to become professor as expected.


Irving L. Weissman
(Stanford University, hematopoetic and cancer stem cell pioneer - or should I say the "Albert Einstein" in stem cell biology? in my view, a clear Nobel candidate, who  later accepted to become my official sponsor at Stanford, although he allowed me to work on and continue my own project; he wrote about me):
"Robert Eibl came to me ... with a very fascinating finding - he showed a role of integrin alpha4beta1 [=VLA-4] using the adhesion process of experimental metastatic melanoma cells.... I happily agreed ... and have been delighted to watch him develop the project ... to an important set of publishable findings. ... articulate and intelligent scientist.  ... I beleive that he is extremely good, and ready to enter ... a beginning research position...."

(Unfortunatele, the German Research Council, DFG, did not found a second year in this famous lab - I may have had the Nobel by now, since I was searching for the first metastatic cell in tumors; but the DFG originally supported me to get my Harvard stipend, and after I couldn't start it within a year, the DFG allowed me to write a similar grant for Stanford University to get into Eugene Butcher's lab - although he never became my official sponsor).


Eugene C. Butcher
(official Nobel equivalent/Crafoord prize winner, Stanford University):      
"....  Robert initiated and  independently carried out studies of CD44 and also a4 integrin involvement in metastatic melanoma cell interactions with vascular endothelium under shear, revealing a critical role for a4b1 [=VLA-4] in particular. Irv Weissman, ... feels that Robert's observations represent a significant contribution to the field. Moreover, these studies were pursued with remarkable independence by Robert. ... he clearly has the potential to contribute to our understanding of the metastatic process. Like Irv, I feel his record of independence make him ready for ... independent research position...."


Paul Kleihues
(Director Emeritus IARC / WHO cancer research center):     
"... He was able to rapidly acquire new laboratory techniques and exhibeted an unusual depth of conceptual thinking. ... A total of 11 publications resulted from his work in our laboratory... I can fully recommend Dr. Robert Eibl for a position in basic medical research..."

(Too bad that, when I was young, I didn't want to be promoted to full professor in his field of neuropathology - I accidentally started after med school in his lab in Zürich, Switzerland, although I never liked neither pathology nor neurology (my doctorate thesis was already finished in molecular cloning), and I never heard before about neuropathology. Unfortunately, Germans laws on getting the final license needed to work in a medical field for 18 months... so I choose an environment with some research lab - and accepted low payment).


Heinz Höfler
(DirectorEmeritus Pathology / Technical University of Munich):    
" .... his newest and very fascinating set of findings use atomic-force microscopy to detect adhesion between two living cells on the level of single-molecules. This clearly is pioneering work and supports  his view of tumor metastasis... I can recommend Dr. Eibl as a highly motivated researcher able to develop independent and important contributions to any field of his choice. ..."  


Older News:

(from a supporting letter to the American Heart Association 1/2004)
Assoc. Prof. Vincent T. Moy, Ph.D. also confirmed my AFM related expertise:
"In particular, the expertise in the AFM technique that he [Robert Eibl, MD] has gained while a member of Dr. Hermann Gaub’s group will be an important asset in his proposed research. To assist Dr. Eibl in achieving his fullest potential [... blablabla snipped]. Dr. Eibl will also be able to consult with collaborators such as Dr. Ronen Alon (Group leader, Immunology, Weizman Institute, Rehovot, Israel; presently Harvard University, Boston), Prof. Dr. Horst Kessler (Head of Organic Chemistry, Technical University of Munich, Germany), Prof. Hermann E. Gaub (Head of Applied Physics, LMU – University of Munich, Germany)."


  I never bought anything to get listed !

(e.g. Who's Who in the World; ... in Medicine; ... Science and Enginiering)


  this is just the QR-code to ORCID and my scientific publications


NEWS - 2018: invited as guest editor for 4 "special issues"  of cancer and metastasis research, cell adhesion, immunology research from intl. publisher, founded by famous double Nobel prize winner Marie Curie almost 100 years ago !



participating at biotech-startup-entrepreneurs course in Heidelberg


October 1st, 2018

NOBEL PRIZE in medicine goes to James P. Allison (from MD Anderson Center, USA) - I had a chance last year to attend his talk at the Royal College of Physicians in London. The MD Anderson Centre provided me with a stipend covering the flight, hotel, meeting - and really great food - just wonderful meeting. It was something special. I am proud having been invited to London at the "Accelerating Cancer Immunotherapy 2017".


September 18, 2018

I enjoyed - in my view a candidate for the Nobel prize - Stanford-Professor Michael Clarke's talk on metastatic cancer stem cells in Heidelberg; he answered my two questions directly in front of the auditorium - which were related to my experimental approach at Stanford, and I also thanked him later for a short discussion on other aspects of metastatic cancer cells.


August 2018

I really enjoyed a wonderful meeting with the search committee and made my genuine proposals ... the next steps may take some time (summer pause).


July 2018 --- I am coauthor on a fundamental, scientific manuscript to be submitted these days to a major, so-called "first class journal", i.e. one of the highest impact factors at all and the number one in its field. (This is totally independent from the other news here):


July 18

I was personally invited to an interesting talk with the new director of the German Cancer Research Center - there will be another meeting with a search committee in August.


June 26:

I am now officially running for the membership of the management board - with just one other candidate (absent) at the time of the official meeting. The board then may elect the new member as chair to succedd Prof. Manfred Schwab, who had succeeded Prof. Peter Bannasch. Meanwhile the finding commission of the DKFZ invited me for an interview.

BTW, the alumni association was initiated by Nobel prize winner Prof. Dr. med. Harald zur Hausen.

The pic below shows me in the late evening - and after a long flight from the USA during which I prepared my presentation on the laptop - after winning the first prize of the first alumni meeting in 2004 - pls note: the director did not participate in my presentation nor was he involved anyhow in the prize committee.




June 7:

one of two candidates for the management board of the German Cancer Research Center/dkfz-alumni organization


June 6:

title submitted for conference talk:

“Single-molecule” force measurements between living cells: AFM elucidates integrin activation by chemokines with implications in cancer stem cell trafficking




June 1st:

I plan to serve as "guest editor" for four "special issues"

I am happy being mentioned in the acknowledgement of the editorial of the brandnew, scientific journal "4open", which got its first article by famous professor Jeffrey Beall in June 2018 - yes, that is the one from "Beall's list" who invented the term of "predatory" journals, which influenced the world of scientific publishing. As a volountary,  "associated editor" of the editorial board my expertise includes cancer research and metastasis, leukocyte trafficking, as well as cell adhesion and biophysics (atomic force microscopy/AFM).


Offers welcome:

group leader position  pharmacology of cell migration, cancer/metastasis research, AFM / biophysics;

Also wanted: 1-10 million EUR venture capital to start my own pharmacology/nanotech company


Invited to a celebration ceremony for the Nobel prize winner

Harald zur Hausen, shortly after the announcement of his award.



my public profile in RESEARCHGATE (click here)

my original publications have been cited about 1300 times

(not included are citations of my -recognized- work in textbooks, e.g. my neurosurgery/medulloblastoma model, which helped in my view to get better diagnostics and treatment of such tumors - probably more than 100 million USD, genetic profiling and application of new therapies lead to the fascinating developments at the German Cancer Research Center, which was led for about a decade by my first postdoctoral supervisor, Prof. Otmar D. Wiestler)







I authored several, major book chapters in nanotechnology and protein-protein interactions:

CLICK HERE  my book chapter of 33 pages.

(series editor includes a Nobel prize winner, Klaus von Klitzing)




My critical "comment" in one of the best of 105 journals of "applied physics" (2014)
Comment on “A method to measure cellular adhesion utilizing a polymer micro-cantilever” [Appl. Phys. Lett. 103, 123702 (2013)].
Applied Physics Letters,2014; 104(23):





This pic was included by Prof. Tina Seelig (Stanford University) as the first of thousands in a final photo montage on Youtube - I was the team lead of 14 students from all around the globe  in a "Crash course on creativity" - with over 39.000 starting participants. We should summarize in six words what we have learned from the course... I am very glad that nobody of my team left it, although I managed (or better: I tried to manage) one of the largest and most international teams from different time zones, background, age ....






To the best of my knowledge to date I was the first:

1) First detection of a p53 mutation in a human medulloblastoma.

My findings on medulloblastomas were published together with Hiroko's data on oligodendrogliomas: Ohgaki, Eibl, et al. CANCER RESEARCH 1991. (Note: at the same time another, the Vogelsetein-group published another p53 mutation in a medulloblastoma cell line, i.e. not within a primary medulloblastoma - therefore I consider me as the very first for original tumor tissue)

2) First detection of a high (50%) frequency of p53 mutations in low-grade astrocytomas (WHO grade II), as well as in anaplastic astrocytomas (WHO grade III) and in Glioblastoma multiforme (GBM WHO grade IV).

These findings were reproduced under my supervision by my trainee from Harvard Medical School and later combined with other (expected) data on the chromosomal loss of the arm harbouring the p53 gene  (von Deimling, Eibl, et al. CANCER RESEARCH 1992). I'm not sure if anyone else before myself also found the high incidence of p53 mutations in low-grade astrocytomas (WHO grade II). Since I never wanted to become full professor of neuropathology I didn't fight for a first authorship of my very first finding of these mutations in the low-grade astrocytomas. I also could not detect any p53 mutations in any of the pilocytic Astrocytomas (similar name, but different biology compared to other astrocytic tumors), but since my supervised guest published our results in Cancer Research, I could not publish the same material as original paper anywhere else.

3) Development of a brain tumor model for PNET (primitive neuroectodermal tumors/medulloblastomas), histologically indistiguishable from human medulloblastoma. First published Abstract: Eibl and Wiestler 1991; Original Paper several years later: Eibl et al. 1994: American Journal of Pathology - With presenting this model in Bonn, O.D. Wiestler became immediately full professor. He continued and was able to reproduce this model in Bonn, where there was already an an established research group in the field of  SV40 large T-antigen, which induced the tumors in my model (with p53 as one known interactions partner of SV40LT).

4.1) First detection of CD44v splice variants in human brain tumors (CD44v found on RNA and protein level, histochemistry, as well as cell sorting and functional assays; Experiments in Karlsruhe) - at the same time others in my lab published with collaborators just the opposite (i.e. they were unable to detect splice variants in such tumors). Their methods and/ their work was not sensitive or accurate enough. I could perform even functional assays on living cells...

4.2) Genomic organisation of  CD44 gene and its variant exons and the end of CD44 gene (mouse library was SV129 strain, unusual, but necessary for isogenic K.O. constructs). Interestingly, this was confirmed and published with only acknowledging me as 'results confirmed by Eibl', without my Southern-Blot findings the length of an intron of several kb could not be detected by PCR as suggested.

5) Unpublished: Tumor cell rolling under shear as a model for organ-specific metastasis. Model for melanoma metastasis. (Experiments in Eugene C. Butcher lab, Stanford University; officially sponsored by Irv Weissman)

6) Unpublished: Physiologic monocyte rolling and CD44 functional experiments/regulation (Collaboration with Dr. Marcus Hubbe, Eugene C. Butcher-lab, Stanford University)

7) First AFM measurment of specific mammalian cell-cell interactions on a single-molecule level. First measurement of VLA-4 / VCAM-1 interaction with AFM and at the single molecule level on living cells (Eibl and Benoit 2004). Experiments started 2001 with Martin Benoit in Hermann E. Gaub - Biophysics lab in Munich, supported with a chemical integrin inhibitor from Horst Kessler (Chemistry, Munich)... I could get very best recommendations from both Professors (and a third collaboration partner, formerly at Harvard) for my 50 pages grant application in the USA, but then the Munich lab started to get my project going in Munich - resulting in several highly questionable master and doctorate theses ...

8) First AFM measurment of activation (modulation) of any integrin by any chemokine on any cell and at the single-molecule level: VLA-4 / SDF-1 / VCAM-1 (Munich and Miami).

(unfortunately, this Nobel-like experiment was overtaken by my collaborators)

9) Unpublished: 2001 Detection of CXCR4 and CCR7 chemokine receptor espression in all types of breast cancer as well as in normal and premalignant mammary gland tissue. (Findings were in contrast to a Nature paper in 2001 by Albert Zlotnik's group). Other chemokine receptors expressed in malignant tissues.





here are just a few of my Fotos (click here), including  several pics and a video of Apollo butterflies (Parnassius apollo) from different spots in Bavaria/Germany (otherwise extinct in most parts of Germany), as well as pics of a totally black snake (melanism), orchids and other wildlife in bavaria
 if the link doesn*t work: http://www.flickr.com/photos/eibl






My moderate (!) LETTER  TO THE EDITOR 06/2008

My following, and as I think, really moderate letter points to clear mistakes in a review of German  biophysisists - which is not corrected by Fiona Watt, Editor in chief of the Journal of Cell Science.
All three of my points have been completely confirmed by independent scientific experts, but none of the critisized authors provided a publishable reply, nor did they support the publicaton of a "correcting addendum" to  their clear mistakes:

- - - - - - - - - - -

Robert Eibl:

Single-receptor adhesion measurements on living cells  

Helenius et al.(1) [Helenius, Heisenberg, Gaub HE, Müller] review the use of atomic force microscopy (AFM) for single-cell force spectroscopy (SCFS). In Table 1 of their report, they list the references for ‘receptor-ligand interactions by SCFS using living cells as probes’. These references include two papers detecting the rupture force of individual cell adhesion bonds of integrin alpha4beta1 (VLA-4) on cells to its ligand VCAM-1. Surprisingly, however, Helenius and co-workers have not included the work of Eibl and Benoit (2) in their commentary, although the findings concerning the same integrin to ligand interaction were published 5 and 18 months, respectively, before the two cited references appeared.  In addition, Table 1 contains two smaller mistakes. First, the work of Thie et al.(3) is used as a reference for the specific measurement of LFA-1 (integrin alphaLbeta2) on its ligand ICAM-1, but these authors never claimed to specifically measure any cell adhesion receptor. To the contrary, they state that they could only speculate regarding the cell adhesion receptors involved, which might include several integrins and other cell adhesion receptors. This citation may also mislead readers with regard to several aspects of the technique for measuring leukocyte homing receptors with AFM at the single-molecule or single-receptor level, including the original developers of the approach and the time-frame in which it was developed. Second, Table 1 also includes a repeated typing error: concavalin A instead of concanavalin A. In my view, a detailed step-by-step protocol in this area could have been included in the review, too (4). For readers interested in an extensive overview of this topic, a book chapter is soon to be published that will also review this subject and include a similar table as well as further protocols for experiments (5). 
(1)  Helenius, J., Heisenberg, C.P., Gaub, H.E., Muller, D.J. (2008). Single-cell force spectroscopy. J. Cell. Sci. 121, 1785-91 
(2)  Eibl, R.H. and Benoit, M. (2004). Molecular resolution of cell adhesion forces. IEE - Nanobiotechnology 151, 128-132  
(3)  Thie M, Röspel R, Dettmann W, Benoit M, Ludwig M, Gaub HE, Denker HW (1998). Interactions between trophoblast and uterine epithelium: monitoring of adhesive forces. Hum Reprod. (11):3211-9
(4)  Eibl, R.H. and Moy V.T. (2005). Atomic force microscopy measurements of protein-ligand interactions on living cells. In: Protein-Ligand Interactions. (Editor: G.Ulrich Nienhaus), Humana Press, Totowa, NJ, U.S.A., pp. 437-448 ISBN 1588293726 
(5)  Eibl, R.H. (in press). Direct force measurements of receptor-ligand interactions on living cells. In: Applied Scanning Probe Methods. Bhushan, B., Fuchs, H., Tomitori, M. (editors), Springer, Heidelberg

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 In 2002 I obtained a governmental stipend from DFG, Bonn (German research foundation) to meet with Harvard Professor Timothy A. Springer (Crafoord prize winner 2004; equivalent to Nobel prize) in the USA  in order to discuss my extremely pioneering projects as a project leader between nanotechnology and immunology, i.e. AFM force measurements of VLA-4 integrin on living lymphocytes and possibly the activation by SDF-1, a project I had planned and developed already since May 2001 !!! Later, I was able to have Professors from Germyany submitting letters of reference to him, including a letter of reference from a famous Professor of Biophysics. Unfortunately, until today Tim Springer himself, as well as the President of Harvard University avoid to confirm any of these facts - and, unfortunately, are not helpful in any way in my fight against severest plagiarism of my life's work. Please note: I don't accuse Tim Springer himself, nor any of his current lab members of plagiarising any of my projects of measuring with AFM on the single molecule level VLA-4 / VCAM-1 interactions on a living cell.


If I remember correctly, the Harvard University is known to be the University of the three lies - for historical reasons, but I wonder how it will be called in the future due to this scientifically very questionnable behaviour.


Interestingly, the University of Munich including its president also tries to avoid the written confirmation of the originality of my project and also my project leadership on measuring VLA-4 (and other homing receptors I was working on long before I shared my knowledge with the University) on living cells (including lymphocytes) with AFM at the single-molecule level and the activation measurements by SDF-1.




older NEWS                   Dec.  2008:

1. Inclusion in Marquis' "Who's Who in Medicine and Healthcare", 2009

2. Robert Eibl on network.NATURE.com http://network.nature.com/people/U81AA8F85/profile

3. INVITED TALK(German Society of Immunology / 35th Annual Meeting of Clinical immunology, Frankfurt am Main):  "Homing: comparison of lymphocytes and metastases"

4. My BOOK CHAPTER (31 pages !!!) appears on Dec. 1st , 2008 in the USA (whole book costs about 199 USD/139.05 EUR) Robert H. Eibl: Direct Force Measurements of Receptor–Ligand Interactions on Living Cells  In: Applied Scanning Probe Methods XII - Characterization. Bhushan B, Fuchs H (Editors), Springer, Heidelberg, pp. 1-31, (2009)

5. Click here to view my public profile on ResearcherID.com



NEWS:  inclusion in Marquis'

"Who's Who" in the World

I should mention that I don't know who nominated me for this inclusion. PLEASE note, I never bought anything from Marquis' Who'swho, nor did I pay anything to be included, nor did I nominate myself in any way.


Here some minor or funny prizes I won in 2008:

1) One of the two major  weekly journals in Germany (Focus) awarded me with a prize for a funny, but potential excuse, which a German museum could have used earlier in 2008. It became the victim of chinese plagiates  and therefore had to close its major exhibition of chinese warriors. My comment is in German language, it mainly critisizes the naive German willingness to beleive everything from anyone - of course, my satirical comment is not intended in any way to critisize chinese culture - we all know nobody could have expected to get the real chinese warriors to Germany, especially by a company not representing Chinese government)




2) I've been awarded from the WDR (large public TV-broadcast) for my published gardeners' tip. I received a valuable book.


News 2007:

Nature-online published a Commentary of  Robert Eibl on the Nobel prize in the field of Embryonic stem cells and K.O. mice ( http://www.nature.com/news/2007/071010/full/449642a.html )

Another comment in 2008 on BSE you will find here, in  Nature.com : ( http://www.nature.com/news/2008/080701/full/news.2008.926.html?q=2#last-comment )

As many of you know  I'm the first scientist measuring with AFM-based single-molecule force spectroscopy  the physiologic activation of any integrin by any chemokine on any cell type. Major molecules of interest: VLA-4, VCAM-1, SDF-1 - but since the beginning of this project in 2001, any  measurement of (rapid) regulation of cell adhesion and the molecular resolution of it came into the focus of my independend research approaches..

A propos, recent (and expected) future Nobel prizes for Stanford University:

In 2006, two Nobel prizes were given to researchers at Stanford Medical School -  I expect more in the coming years.
1) Nobel prize in Physiology and Medicine: Andrew Fire (Pathology and Genetics)
2) Chemistry: Roger Kornberg (Structural Biology)

- still remembering his very clear  lecture and discussion with him I sent congratulations.
Thanks to Stanford to accept my second comment:
".... the comments of Robert Eibl, Bad Reichenhall, Germany, October 9, 2006 04:33 AM
As a former postdoc in Weissman lab, I expected at least one Nobel prize to go to the Stanford University School of Medicine in the coming years. I remember a great lecture of and a short discussion with Roger Kornberg during my years at Stanford. This prize is sure a wonderful and great honor for him and his work, but also for the 'little' Stanford School of Medicine receiving even two prizes in one week (Andy Fire for Medicine and Roger Kornberg for Chemistry). For me it was a great honor to improve my scientific education and serve the School of Medicine as a postdoc. Congratulations to the Nobelist !"


Academic references/Professors:

Irving L. Weissman (M.D.)
my official sponsor at Stanford University - except the Nobel, many intl. awards

Eugene C. Butcher (M.D.)
he provided the lab equipment I needed for my independent research concept on VLA-4/VCAM-1 and living cells; he received the swedish Crafoord prize 2004 which is the only official equivalent to the Nobel prize (a former member of Weissman lab)

Paul Kleihues (M.D.)
former director of IARC, Lyon; former Head of Neuropathology, Univ. Zürich

Otmar D. Wiestler (M.D.), President, Helmholtz society (from 2015); Director, DKFZ German cancer research center (until 2015), Heidelberg

Heinz Höfler (M.D.)
Head of Pathology, Technical University of Munich

Dieter Werner (Ph.D.)
lab head (retired) "Biochemistry of the Cell" at the Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg


In 2001 I developed my research concept which in my view and especially at that time was really great. Unfortunately, the collaborating biophysics lab was unable to support me as a long-year guest scientist with this project to the extend necessary to get this into Cell, Science or Nature. 

Although I had several abstracts since 2001 with the lab, but none of my expected, perhaps five,  manuscripts in preparation was close to be finished by the lab in 2003, I was able to submit in September 2003 the first AFM measurements of VLA-4/VCAM-1 on a living cell in a smaller journal - I was really upset about collaborating over years with a lab unable to focus on publishing my research concepts in first class journals. Without my paper, it would be harder to prove that I really was the first - and that the lab later just continued with my research concept and other collaborations that I initiated and organized by myself. To my surprise, the lab and the university still actively avoid mentioning my publication in a students' thesis, as well as on the official university webpage with the lab publications list.

Real and virtual morrors: Two pairs of dragonflies. Can they sense their existense for a short summer? If yes, can they also sense the surrealism in this pic?



hard to find: Lady's-slipper orchid (in untouched nature, Bayerisch Gmain, GERMANY)

please note: two flowers at one plant (instead of the "usual" one)