SNOWBOARDING: December 2017, www.goetschen.com in Bavaria

Welcome to my private Homepage             under construction

robert.eibl(at)alumni.dkfz.de

Cell migration analysis 2017: my cells run fast (here: with a chemokine);

please note: semi-automated analysis of time-lapse video-microscopy (not my analysis); photo taken from mirroring monitor

 

 

NEWS - 2018:

I am more than glad being mentioned (even twice) by the founding editor in his very first "Editorial" of the new, international, scientific and medical journal "4open".

As a member of the EDITORIAL BOARD my expertise includes cancer metastasis, cell trafficking and biophysics (atomic force microscopy, AFM) - I hope to be able soon to support this new journal to the success it deserves.

 

"California Moon"/variants on my balcony 2017

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+++++ offers welcome: group leader position / assistant professorship in my pioniered field of cancer research and/or biophysics/immunology/cell adhesion; also wanted: 1 mio. EUR/USD seed money/venture capital to start my own biotech/pharma/nanotech company +++++

recently finished "with distinction" a entrepreneurial Stanford University online course (Business School)

recently volounteer "instructor" for an online-course at UC San Diego

 (old pic/old boat, near street of Gibraltar, Spain: just before heavy weather - those rare sailing pics are misleading: I like more windsurfing at extremely windy, but sunny days with 6-9 beaufort, just before hurricane-strong winds, i.e. too much wind for nice sailing).

 

(new pic/new boat/Lake Chiemsee, Bavaria): Captain w/o wind - like a scientific pionier w/o support)

"A Nobel prize won't be that easy"

 

Although others plagiarized my life's work I want to continue my extremely pioniering work between nanotechnology and cancer metastasis research, including some aspects of immunology/homing and signal transduction/cell adhesion; therefore I need just a lab with a simple AFM (atomic force microscope) and basic cell culture. Of course, some seed money would be helpful.

This pic from Bavaria was included as the first of thousands in a final photo montage on youtube - I was the team lead of 14 from all around the globe (11 countries) in an online "Crash course on creativity" offered by Prof. Tina Seelig (Stanford University) - over 39.000 participants. We should summarize in six words what we have learned from the course...

My other Stanford online courses included:

Technology Entrepreneurship I (team leader), II

Scaling Up Your Venture Without Screwing Up

Writing in the Sciences (with distinction)

The best course ever: 

Drug Discovery, Development & Commercialization

at UCSD; participant of a selected class of 100 out of 14.000 participants

 

My recent "comment" in the best of 105 journals of "applied physics" (2014)


Comment on “A method to measure cellular adhesion utilizing a polymer micro-cantilever” [Appl. Phys. Lett. 103, 123702 (2013)].
Applied Physics Letters,2014; 104(23):

 

 

My "original" publications have been  cited >1200 times (click to see ref. at google.scholar).

Please note:

1) Most of my recent "book chapters" are not counted as "original work", and therefore won't be cited often - but I had to publish it that way to proof that I was the first - my confidential results (from Stanford) and continued projects and ideas in Munich leaked out (to Miami) and later competitors and collaborators (Munich, Miami, Boston/Rehovot) overtook my life's work - and tried to continue it to some extent, but fortunately, my biomedical background never really leaked out... Still enough room for a Nobel prize ;-)

2) my older brain tumor model on medulloblastomas/PNETs is cited very often in many textbooks of neurosurgery of neuropathology, including the WHO classification of brain tumors and many other textbooks - but those numerous citations do not count in the number of "citations". My original work could be reproduced and helped many professors in their carreers.

 

 

News 2013

33 pages Book Chapter in

Biophysics/Nanotechnology/Cell Adhesion:

Single-Molecule Studies of Integrins by AFM-Based Force Spectroscopy on Living Cells (click on Link/Springer)

 

Older News:

(from a supporting letter to the American Heart Association 1/2004)
Assoc. Prof. Vincent T. Moy, Ph.D. also confirmed my AFM related expertise:
"In particular, the expertise in the AFM technique that he [Robert Eibl, MD] has gained while a member of Dr. Hermann Gaub’s group will be an important asset in his proposed research. To assist Dr. Eibl in achieving his fullest potential [... blablabla snipped]. Dr. Eibl will also be able to consult with collaborators such as Dr. Ronen Alon (Group leader, Immunology, Weizman Institute, Rehovot, Israel; presently Harvard University, Boston), Prof. Dr. Horst Kessler (Head of Organic Chemistry, Technical University of Munich, Germany), Prof. Hermann E. Gaub (Head of Applied Physics, LMU – University of Munich, Germany)."

 

Other NEWS (2014)

 

(I just happily found out that my photograph of an almost extinct Florida butterfly, the Miami blue, was used and correctly cited with my name in several reports in the last years, for example here: Link )

It took decades to get this now heavily protected by US-law; it took decades from the first signs of loosing this species in 1984; with not a single view after hurricane Andrew hit Florida in 1992, although many major butterfly experts from around the world could not find it for six consecutive years - and they looked at any little, tiny island around the Florida Keys ... but then one colony with 49 and two butterflies on one Key were found... I expect this species will not make it in Florida, it may just be too sensitive to something, like hurricanes or anti-mosquito insectizides.

 

 

3/2013: (observation in unmodified nature)

a frog swims with a salamander (click here for youtube video 3/2013)

 

The German Police in 2012 acknowledged my awareness to recognize a potential crime and to bring it to their attention - they had first to check with experts and with the state attorney, but later could confirm that I really was right about my impression, and that nobody else of thousands of others did realize it. They stopped the crime. Now they were trained in an uncommon field.

 

I recently finished as first of originally over 39.000 accepted participants in an online "Crash course on Creativity" offered by Stanford University... (a Venture Lab course from Prof. Tina Seelig)

In another course from Stanford University I accomplished my course  "Writing in the Sciences". I am very proud to finish this extremely helpful course "with distinction" since my english still shows room for improvement (a coursera course by Prof. Kristin Sainani, PhD) - now, I feel confident enough to write up a number of papers in the pipeline...

 


News 2012

Interestingly, a plagiarized paper has now been removed from the publication list of a Bavarian biophysics' webpage - and one of the contributing authors is not listed as former member of that lab !!!

Several plagiarists are not listed as former members of the questionable lab.

 

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October 2008

Invited to a celebration ceremony with the Nobel prize winner 2008.

 

 

CLICK HERE  my book chapter of 33 pages.

(series editor includes a Nobel prize winner)

 

 

hard to find: Lady's-slipper orchid (in untouched nature, Bayerisch Gmain, GERMANY)

please note: two flowers at one plant (instead of the "usual" one)


    My first convertible in 1997-99:

a comfortable Australian Mercury Capri - here at Golden Gate bridge, California. Back in Germany, I drove a silver one - to my surprise up to 200km/h. Later, back in the USA, I found a cheap,  318iS BMW convertible in Florida/Miami/Key Biscayne - which I took back to Germany - easy to put my large Mountainbike on the three remeining seats:

 

 (Bahia Honda, one of the Florida Keys - escaping to Key West just a day before one of "my" big four hurricanes, happily survived)

 

 

  "My private beach access" on Key Biscayne, FL: I enjoyed for over a year this quiet, unique and lovelycoconut island, just 10 min to the University hospital in Miami (some of my colleagues living in crazy Miami Beach often needed 2-3 hours for the same distance).

The (sub-)tropical island and "village" of Key Biscayne with only 10,000 inhabitants is extremely quiet, surprisingly safe - although just next to rather wild and crazy Miami and Miami Beach. I thought I would become Assistant professor at the university, but my life's project was then just overtaken in Munich and Miami - and in quite contrast to the NIH salary rules I did not even get the expected minimum salary.


 

   Parnassius apollo - Red Apollo butterfly

(extinct in almost all areas of Germany during the last 150 years - due to environmental changes plus collectors extreme enthusiasm)

This butterfly species is heavily protected in Germany since over 100 years, but got extinct almost everywhere - except in the Alps and the Mosel valley.

My VIDEO (click here) of exactly this butterfly is on FLICKR www.flickr.de/eibl 


my public profile in RESEARCHGATE (click here)

my original publications have been cited about 950 times

(not included are citations of my work in textbooks, e.g. my neurosurgery/medulloblastoma model)

 

MY SCIENTIFIC ACCOMPLISHMENTS

To the best of my knowledge to date I was the first:

1) First detection of a p53 mutation in a human medulloblastoma.

This was published with other data on oligodendrogliomas: Ohgaki, Eibl, et al. CANCER RESEARCH 1991. (Note: at the same time another, already famous group  published another p53 mutation in these tumors, but found it only in a cell line, i.e. not in a primary medulloblastoma - therefore I was the very first)

2) First detection of a high (50%) frequency of p53 mutations in low-grade astrocytomas (WHO grade II), as well as in anaplastic astrocytomas (WHO grade III) and in Glioblastoma multiforme (GBM WHO grade IV).

These findings were reproduced under my supervision by my trainee from Harvard Medical School and later combined with other (expected) data on the chromosomal loss of the arm harbouring the p53 gene  (von Deimling, Eibl, et al. CANCER RESEARCH 1992). I'm not sure if anyone else before myself also found the high incidence of p53 mutations in low-grade astrocytomas (WHO grade II). Since I never wanted to become full professor of neuropathology I didn't fight for a first authorship of my very first finding of these mutations in the low-grade astrocytomas. I also could not detect any p53 mutations in any of the pilocytic Astrocytomas (similar name, but different biology compared to other astrocytic tumors), but since my supervised guest published our results in Cancer Research, I could not publish the same material as original paper anywhere else.

3) Development of a brain tumor model for PNET (primitive neuroectodermal tumors/medulloblastomas), histologically indistiguishable from human medulloblastoma. First published Abstract: Eibl and Wiestler 1991; Original Paper several years later: Eibl et al. 1994: American Journal of Pathology - With presenting this model in Bonn, O.D. Wiestler became immediately full professor. He continued and was able to reproduce this model in Bonn, where there was already an an established research group in the field of  SV40 large T-antigen, which induced the tumors in my model (with p53 as one known interactions partner of SV40LT).

4.1) First detection of CD44v splice variants in human brain tumors (CD44v found on RNA and protein level, histochemistry, as well as cell sorting and functional assays; Experiments in Karlsruhe) - at the same time others in my lab published with collaborators just the opposite (i.e. they were unable to detect splice variants in such tumors). Their methods and/ their work was not sensitive or accurate enough. I could perform even functional assays on living cells...

4.2) Genomic organisation of  CD44 gene and its variant exons and the end of CD44 gene (mouse library was SV129 strain, unusual, but necessary for isogenic K.O. constructs). Interestingly, this was confirmed and published with only acknowledging me as 'results confirmed by Eibl', without my Southern-Blot findings the length of an intron of several kb could not be detected by PCR as suggested.

5) Unpublished: Tumor cell rolling under shear as a model for organ-specific metastasis. Model for melanoma metastasis. (Experiments in Eugene C. Butcher lab, Stanford University; officially sponsored by Irv Weissman)

6) Unpublished: Physiologic monocyte rolling and CD44 functional experiments/regulation (Collaboration with Dr. Marcus Hubbe, Eugene C. Butcher-lab, Stanford University)

7) First AFM measurment of specific mammalian cell-cell interactions on a single-molecule level. First measurement of VLA-4 / VCAM-1 interaction with AFM and at the single molecule level on living cells (Eibl and Benoit 2004). Experiments started 2001 with Martin Benoit in Hermann E. Gaub - Biophysics lab in Munich, supported with a chemical integrin inhibitor from Horst Kessler (Chemistry, Munich)... I could get very best recommendations from both Professors (and a third collaboration partner, formerly at Harvard) for my 50 pages grant application in the USA, but then the Munich lab started to get my project going in Munich - resulting in several highly questionable master and doctorate theses ...

8) First AFM measurment of activation (modulation) of any integrin by any chemokine on any cell and at the single-molecule level: VLA-4 / SDF-1 / VCAM-1 (Munich and Miami).

(unfortunately, this Nobel-like experiment was overtaken by my collaborators)

9) Unpublished: 2001 Detection of CXCR4 and CCR7 chemokine receptor espression in all types of breast cancer as well as in normal and premalignant mammary gland tissue. (Findings were in contrast to a Nature paper in 2001 by Albert Zlotnik's group). Other chemokine receptors expressed in malignant tissues.

 

TO SEE MY PUBLICATIONS, PLEASE USE THE LINK "PUBLICATIONS, awards" (top left of this page).

 

 

 

 

Here are 5 additional online publications (two NATURE, but not listed in the link above. - For 'real publications' please click on the link above, top left: PUBLICATIONS, Awards, then scroll down):

 

1. Robert Eibl: Commentary to Allison Abbott: “Biologists claim Nobel prize with a knock-out”. URL: http://www.NATURE.com/news/2007/071010/full/449642a.html Published 2007-10-15

2. Robert Eibl: Commentary to Matt Kaplan: “Prions’ great escape”, URL: http://www.NATURE.com/news/2008/080701/full/news.2008.926.html Published 2008-07-04

3. Robert Eibl: Complete citation of former commentary in NatureNews. Jolyon: “Prion disease risk wider than thought?” In: Re Risk: Risk, Re-/Insurance and Future Thinking. http://www.rerisk.net/2008/09/06/prion-disease-risk-wider-than-thought/ Published 2008-09-06

4. Robert Eibl: Recommendation for gardeners: “Schädlinge bekämpfen I” In: “ARD Ratgeber Heim + Garten” (German TV series) Published online, as well as in printed book, ISBN, 2008

5. Dr. Robert Eibl: Short reasoning and (accepted) suggestion in German language why I.L.Weissman should be considered as one of the best scientists. Focus online, “Irving L. Weissman: Mit Mäusen Krebs besiegen” URL: http://www.FOCUS.de/wissen/wissenschaft/wissenschaftlervoting/irving-l-weissman-mit-maeusen-den-krebs-besiegen_aid_372514.html Published 2009-02-17

 

 

 

here are just a few of my Fotos (click here), including  several pics and a video of Apollo butterflies (Parnassius apollo) from different spots in Bavaria/Germany (otherwise extinct in most parts of Germany), as well as pics of a totally black snake (melanism), orchids and other wildlife in bavaria
 if the link doesn*t work: http://www.flickr.com/photos/eibl

 

Due to my pioneering work between Life Sciences and Nanotechnology I was included into:

"Who'sWho" in the World, 27th Edition 2011

 

I've been accepted in the career network of the Stanford University Medical Center Alumni with a focus on workplace issues, including the dealing with problems of international guests, as well as first authorship and PLAGIARISM.

 

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Here are selected citations from "LORs", LETTERS of RECOMMENDATION, from the following Full Professors, also supporting my independent VLA-4 (as well as VCAM-1 and SDF-1) - projects since my time at Stanford University. I also visited biophysics labs in Munich and Miami where I introduced and continued my project on my own ideas. Unfortunately, I didn't get the expected funding in Miami to become professor.

Irving L. Weissman
(Stanford University, stem cell pioneer and, in my view, a Nobel candidate):
"Robert Eibl came to me ... with a very fascinating finding - he showed a role of integrin alpha4beta1 [=VLA-4] using the adhesion process of experimental metastatic melanoma cells.... I happily agreed ... and have been delighted to watch him develop the project ... to an important set of publishable findings. ... articulate and intelligent scientist.  ... I beleive that he is extremely good, and ready to enter ... a beginning research position...."

Eugene C. Butcher
(Crafoord winner 2004, Stanford University):      
"....  Robert initiated and  independently carried out studies of CD44 and also a4 integrin involvement in metastatic melanoma cell interactions with vascular endothelium under shear, revealing a critical role for a4b1 [=VLA-4] in particular. Irv Weissman, ... feels that Robert's observations represent a significant contribution to the field. Moreover, these studies were pursued with remarkable independence by Robert. ... he clearly has the potential to contribute to our understanding of the metastatic process. Like Irv, I feel his record of independence make him ready for ... independent research position...."

Paul Kleihues
(Director Emeritus IARC / WHO cancer research center):     
"... He was able to rapidly acquire new laboratory techniques and exhibeted an unusual depth of conceptual thinking. ... A total of 11 publications resulted from his work in our laboratory... I can fully recommend Dr. Robert Eibl for a position in basic medical research..."

Heinz Höfler
(Director Pathology / Technical University of Munich):    
" .... his newest and very fascinating set of findings use atomic-force microscopy to detect adhesion between two living cells on the level of single-molecules. This clearly is pioneering work and supports  his view of tumor metastasis... I can recommend Dr. Eibl as a highly motivated researcher able to develop independent and important contributions to any field of his choice. ..."   

 

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My moderate (!) LETTER  TO THE EDITOR 06/2008

My following, and as I think, really moderate letter points to clear mistakes in a review of German  biophysisists - which is not corrected by Fiona Watt, Editor in chief of the Journal of Cell Science.
All three of my points have been completely confirmed by independent scientific experts, but none of the critisized authors provided a publishable reply, nor did they support the publicaton of a "correcting addendum" to  their clear mistakes:

- - - - - - - - - - -

Robert Eibl:

Single-receptor adhesion measurements on living cells  

Helenius et al.(1) [Helenius, Heisenberg, Gaub HE, Müller] review the use of atomic force microscopy (AFM) for single-cell force spectroscopy (SCFS). In Table 1 of their report, they list the references for ‘receptor-ligand interactions by SCFS using living cells as probes’. These references include two papers detecting the rupture force of individual cell adhesion bonds of integrin alpha4beta1 (VLA-4) on cells to its ligand VCAM-1. Surprisingly, however, Helenius and co-workers have not included the work of Eibl and Benoit (2) in their commentary, although the findings concerning the same integrin to ligand interaction were published 5 and 18 months, respectively, before the two cited references appeared.  In addition, Table 1 contains two smaller mistakes. First, the work of Thie et al.(3) is used as a reference for the specific measurement of LFA-1 (integrin alphaLbeta2) on its ligand ICAM-1, but these authors never claimed to specifically measure any cell adhesion receptor. To the contrary, they state that they could only speculate regarding the cell adhesion receptors involved, which might include several integrins and other cell adhesion receptors. This citation may also mislead readers with regard to several aspects of the technique for measuring leukocyte homing receptors with AFM at the single-molecule or single-receptor level, including the original developers of the approach and the time-frame in which it was developed. Second, Table 1 also includes a repeated typing error: concavalin A instead of concanavalin A. In my view, a detailed step-by-step protocol in this area could have been included in the review, too (4). For readers interested in an extensive overview of this topic, a book chapter is soon to be published that will also review this subject and include a similar table as well as further protocols for experiments (5). 
(1)  Helenius, J., Heisenberg, C.P., Gaub, H.E., Muller, D.J. (2008). Single-cell force spectroscopy. J. Cell. Sci. 121, 1785-91 
(2)  Eibl, R.H. and Benoit, M. (2004). Molecular resolution of cell adhesion forces. IEE - Nanobiotechnology 151, 128-132  
(3)  Thie M, Röspel R, Dettmann W, Benoit M, Ludwig M, Gaub HE, Denker HW (1998). Interactions between trophoblast and uterine epithelium: monitoring of adhesive forces. Hum Reprod. (11):3211-9
(4)  Eibl, R.H. and Moy V.T. (2005). Atomic force microscopy measurements of protein-ligand interactions on living cells. In: Protein-Ligand Interactions. (Editor: G.Ulrich Nienhaus), Humana Press, Totowa, NJ, U.S.A., pp. 437-448 ISBN 1588293726 
(5)  Eibl, R.H. (in press). Direct force measurements of receptor-ligand interactions on living cells. In: Applied Scanning Probe Methods. Bhushan, B., Fuchs, H., Tomitori, M. (editors), Springer, Heidelberg

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 In 2002 I obtained a governmental stipend from DFG, Bonn (German research foundation) to meet with Harvard Professor Timothy A. Springer (Crafoord prize winner 2004; equivalent to Nobel prize) in the USA  in order to discuss my extremely pioneering projects as a project leader between nanotechnology and immunology, i.e. AFM force measurements of VLA-4 integrin on living lymphocytes and possibly the activation by SDF-1, a project I had planned and developed already since May 2001 !!! Later, I was able to have Professors from Germyany submitting letters of reference to him, including a letter of reference from a famous Professor of Biophysics. Unfortunately, until today Tim Springer himself, as well as the President of Harvard University avoid to confirm any of these facts - and, unfortunately, are not helpful in any way in my fight against severest plagiarism of my life's work. Please note: I don't accuse Tim Springer himself, nor any of his current lab members of plagiarising any of my projects of measuring with AFM on the single molecule level VLA-4 / VCAM-1 interactions on a living cell.

 

If I remember correctly, the Harvard University is known to be the University of the three lies - for historical reasons, but I wonder how it will be called in the future due to this scientifically very questionnable behaviour.

 

Interestingly, the University of Munich including its president also tries to avoid the written confirmation of the originality of my project and also my project leadership on measuring VLA-4 (and other homing receptors I was working on long before I shared my knowledge with the University) on living cells (including lymphocytes) with AFM at the single-molecule level and the activation measurements by SDF-1.

 

 

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older NEWS                   Dec.  2008:

1. Inclusion in Marquis' "Who's Who in Medicine and Healthcare", 2009

2. Robert Eibl on network.NATURE.com http://network.nature.com/people/U81AA8F85/profile

3. INVITED TALK(German Society of Immunology / 35th Annual Meeting of Clinical immunology, Frankfurt am Main):  "Homing: comparison of lymphocytes and metastases"

4. My BOOK CHAPTER (31 pages !!!) appears on Dec. 1st , 2008 in the USA (whole book costs about 199 USD/139.05 EUR) Robert H. Eibl: Direct Force Measurements of Receptor–Ligand Interactions on Living Cells  In: Applied Scanning Probe Methods XII - Characterization. Bhushan B, Fuchs H (Editors), Springer, Heidelberg, pp. 1-31, (2009)

5. Click here to view my public profile on ResearcherID.com



  

NEWS:  inclusion in Marquis'

"Who's Who" in the World


I should mention that I don't know who nominated me for this inclusion. PLEASE note, I never bought anything from Marquis' Who'swho, nor did I pay anything to be included, nor did I nominate myself in any way.

 

Here some minor or funny prizes I won in 2008:

1) One of the two major  weekly journals in Germany (Focus) awarded me with a prize for a funny, but potential excuse, which a German museum could have used earlier in 2008. It became the victim of chinese plagiates  and therefore had to close its major exhibition of chinese warriors. My comment is in German language, it mainly critisizes the naive German willingness to beleive everything from anyone - of course, my satirical comment is not intended in any way to critisize chinese culture - we all know nobody could have expected to get the real chinese warriors to Germany, especially by a company not representing Chinese government)

 

http://www.focus.de/intern/archiv/Archiv_aid_229923.html

 

2) I've been awarded from the WDR (large public TV-broadcast) for my published gardeners' tip. I received a valuable book.

 

News 2007:

Nature-online published a Commentary of  Robert Eibl on the Nobel prize in the field of Embryonic stem cells and K.O. mice ( http://www.nature.com/news/2007/071010/full/449642a.html )

Another comment in 2008 on BSE you will find here, in  Nature.com :  ( http://www.nature.com/news/2008/080701/full/news.2008.926.html?q=2#last-comment )
 

As many of you know  I'm the first scientist measuring with AFM-based single-molecule force spectroscopy  the physiologic activation of any integrin by any chemokine on any cell type. Major molecules of interest: VLA-4, VCAM-1, SDF-1 - but since the beginning of this project in 2001, any  measurement of (rapid) regulation of cell adhesion and the molecular resolution of it came into the focus of my independend research approaches..

A propos, recent (and expected) future Nobel prizes for Stanford University:

In 2006, two Nobel prizes were given to researchers at Stanford Medical School -  I expect more in the coming years.
1) Nobel prize in Physiology and Medicine: Andrew Fire (Pathology and Genetics)
2) Chemistry: Roger Kornberg (Structural Biology)

- still remembering his very clear  lecture and discussion with him I sent congratulations.
Thanks to Stanford to accept my second comment:
".... the comments of Robert Eibl, Bad Reichenhall, Germany, October 9, 2006 04:33 AM
As a former postdoc in Weissman lab, I expected at least one Nobel prize to go to the Stanford University School of Medicine in the coming years. I remember a great lecture of and a short discussion with Roger Kornberg during my years at Stanford. This prize is sure a wonderful and great honor for him and his work, but also for the 'little' Stanford School of Medicine receiving even two prizes in one week (Andy Fire for Medicine and Roger Kornberg for Chemistry). For me it was a great honor to improve my scientific education and serve the School of Medicine as a postdoc. Congratulations to the Nobelist !"

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Academic references/Professors:

Irving L. Weissman (M.D.)
my official sponsor at Stanford University - except the Nobel, many intl. awards

Eugene C. Butcher (M.D.)
he provided the lab equipment I needed for my independent research concept on VLA-4/VCAM-1 and living cells; he received the swedish Crafoord prize 2004 which is the only official equivalent to the Nobel prize (a former member of Weissman lab)

Paul Kleihues (M.D.)
former director of IARC, Lyon; former Head of Neuropathology, Univ. Zürich

Otmar D. Wiestler (M.D.), President, Helmholtz society (from 2015); Director, DKFZ German cancer research center (until 2015), Heidelberg

Heinz Höfler (M.D.)
Head of Pathology, Technical University of Munich

Dieter Werner (Ph.D.)
lab head (retired) "Biochemistry of the Cell" at the Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg

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In 2001 I developed my research concept which in my view and especially at that time was really great. Unfortunately, the collaborating biophysics lab was unable to support me as a long-year guest scientist with this project to the extend necessary to get this into Cell, Science or Nature. 

Although I had several abstracts since 2001 with the lab, but none of my expected, perhaps five,  manuscripts in preparation was close to be finished by the lab in 2003, I was able to submit in September 2003 the first AFM measurements of VLA-4/VCAM-1 on a living cell in a smaller journal - I was really upset about collaborating over years with a lab unable to focus on publishing my research concepts in first class journals. Without my paper, it would be harder to prove that I really was the first - and that the lab later just continued with my research concept and other collaborations that I initiated and organized by myself. To my surprise, the lab and the university still actively avoid mentioning my publication in a students' thesis, as well as on the official university webpage with the lab publications list.

Real and virtual morrors: Two pairs of dragonflies. Can they sense their existense for a short summer? If yes, can they also sense the surrealism in this pic?

 

 

This blue, "iris" looking "Great Emperor" (German: Großer Schillerfalter) butterfly is officially much more common than the Red Apollo, but it took me 30 years to get it in front of a camera like this (2010) - but couldn't find the population in 2011 with a better camera.

 

 

I would like to  protect my strange, but fascinating "medusa-like" flowers, which show a striking phenomenon of "multiple flower heads growing out of a single flower head" - this variation of flowers currently grows in its 5th year and should be used for stem-cell biology and cancer/metastasis research (see one video on youtube - showing the offspring of the original plant with identical mutation/phenomenon). The current (2011) generation also grows from seeds out of secondary flowers (flowers from flowers), which could be clones (which where infertile the years before).

Old videos (with 2 MegaPixel Nikon Camera):

1) little Iguana  at the pool in Florida

 

 

2) "my"  beach on Key Biscayne

3-17)  various other short videos of nature in Florida/Key Biscayne (my youtube-ID is nobel2020 ), but all vids are made with a Nikon 2002 photocamera (2 Megapixel at that time !!!)

 

 

Bavaria with my MTB from Miami (right) - I observed these trees for years before an orkan "modified" them - but they continue to grow. Need to find the "before" pics...

 

 

Wild flower (typical for Bavaria).

 

Miami Beach (usually crowded, touristic, strange - I preferred living at a close island, quite a contrast: calm, safe, quite normal, no crimes, basically no visitors, no parking lots for visitors outside the empty, but top two public beaches (Top 10 in the US, incl. Hawai)

  

Sunset on Key Biscayne

(where I often had a walk or bike ride just before official closing of the Bill Baggs Florida park - many dead looking snakes on the warm trails in the evening usually are not dead)